Once a vial of bacteriostatic water is opened, the benzyl alcohol will usually prevent the growth of bacteria for up to 28 days. Lets nail the major differences right from the start. The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. There are not many side effects associated with using bacteriostatic water. Composed of sterile water and 0.9% benzyl alcohol and an organic preservative agent, bacteriostatic water resists bacterial growth and contamination [1]. RxList does not provide medical advice, diagnosis or treatment. Handlers should follow the applicable dosage and administration schedule [16]. Peptide Dosing Guide. 420 Throckmorton Street, Suite 200, Fort Worth Texas 76102, Copyright 2022 BacteriostaticWater.com - All Rights Reserved, Wholesale Hospira Bacteriostatic Water Supplier, Need help? Most peptides that you will see are often sold as lyophilized peptides which means that (freeze-dried) powder form. It is commonly used to reconstitute or dilute therapeutic substances for injection, including intramuscular, intravenous, intradermal, and subcutaneous routes [1, 2]. While there is not a long-term shortage, an acute shortage is often seen because of either manufacturing facilities malfunction or some medical emergency such as COVID-19. Mrose . The dosage and administration schedule should follow applicable recommendations [18, 19]. Drug class: Sterile irrigating solutions. Before really going straight into the topic, lets first understand the need for the phrase reconstituting peptides. Should I dilute with sterile water (USP grade) or BW? The packaged diluent (Bacteriostatic Water for Injection) contains benzyl alcohol as a preservative. and our It is essential to avoid repeated freeze-thaw cycles and exposure to light and high temperatures. Contraindications for bacteriostatic water injections include newborn babies and cerebrospinal injections [2, 8]. See WARNINGS, PRECAUTIONS Bacteriostatic water (BW) has a pH of about 5.7. Another difference is indications. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. Other side effects from bacteriostatic water have been reported to include tissue death, venous thrombosis, infection at the injection site, fever, abscess formation as well as a febrile response. Recommended dosage guidelines are usually based on either the clinical trials or the efficacy of the peptide. In summary, the best way to store reconstituted peptides depends on the duration of storage and the desired shelf life. Besides neonates, they both can be used for the rest of the population including pediatrics, adults and the geriatric community. You can go as high as 2 milliliters per peptide reconstitution as it does no harm other than more dilution. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Perhaps other adverse effects include fever, abscess formation, thrombosis, tissue death, and infection. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. Example would be 5g of CJC-1295 and 5g of ipamorelin. RedwolfWV Registered User Awards 1 May 24, 2008 #4 Ahh I get it. I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. Because of the benzyl alcohol contained in Bacteriostatic Water for Injection, USP, when doses greater than . Last reviewed on RxList: 10/13/2021 Though their features overlap, bacteriostatic water and sterile water have several significant differences. Bacteriostatic water is usually the term given to a commercial preparation (made by Hospira, for example), whereas reconstitution solution is the term given by a smaller (usually underground) company that makes its own to sell. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. Bacteriostatic Water for Injection may kill some of the vegetative cells if present as contaminants. There are no adverse or bad side effects of using sterile water in small doses, one should never take it intravenously. Water for Injection, USP is chemically designated H2O. ResearchPeptides.org follows the strictest sourcing guidelines in the health and nootropics industry. All of our content is written by people with a strong science background, including medical researchers. If you are already registered, please log in. Validation of these types of filling operations should include media fills and the sampling of critical surfaces and air during active filling (dynamic conditions). ZOMACTON 10 mg reconstituted with bacteriostatic water for injection containing 0.33% metacresol should not be used if the patient is allergic to metacresol. Ob es sich um die Verwaltung von Kundeninvestitionen oder einen umfassenden Plan fr sie zu schaffen und ihre Familie sind unsere zertifizierten Planern gewidmet mit einem auergewhnlichen Service zu bieten. Muscle + Brawn is independent and reader-supported. Consult with pharmacist, if available. Most peptide packages contain mixing instruction. You don't use either to reconstitute it. A generally recognized acceptable method of sterilizing the lyophilizer is through the use of moist steam under pressure. Air oxidation is yet another threat to the efficacy of the peptide, especially some peptides having amino acids such as free cysteine and tryptophan. However, there are some differences between the two. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. For safe storage, adhere to manufacturer indications. The first step is to use the alcohol swab and wipe the vials containing lyophilized peptides and the bacteriostatic/sterile water. The container requires no vapor barrier to maintain the proper labeled volume. If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Home > Peptides > Peptide Reconstitution + Mixing Guide with Calculator. This guide has you covered. Parenteral drug products should be inspected visually for particulate matter The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. In case you experience any of these side effects, you should immediately stop using sterile water for injections and talk to a doctor. As the title suggestswhats the difference between bacteriostatic water and reconstitution solution? Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. More posts from r/Peptides 46K subscribers Hour_Love5645 6 days ago NSFW Some measures are necessary - do not inject the water straight into the powder with force, usually, do not drop or shake a reconstituted vial. The starter set has all you need to get going, including the following: If you want a little more, check out the premium kit: Qualified handlers are sure to enjoy this top online source for research materials. You are granted limited license only for purposes of viewing the material contained on this Website. Cloudflare Ray ID: 7c0dd6108cb23fde Sterile water is formulated for irrigation, such as rinsing wounds, unlike bacteriostatic water. If you feel that any of our content is inaccurate or out-of-date, please contact us at: [emailprotected]. .063 mg/mL, 3200 mL c. 1000 mg/mL, 5 mL d. 64 mg/mL b. Lysis is the breaking down of a cell or membrane. When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days. This article will guide you step-by-step on how to mix your peptides well enough and will clear all your questions so that you can enjoy the maximum efficacy of peptides. Well, people have been mixing peptides in the same syringe and then administering them. Only if the peptides are of the same nature such as growth hormone (GH) influencers or if you see any vendors selling a stack of particular peptides, only those you should mix. Bacteriostatic Water may be used alone or with other medications. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Privacy Policy. Now, before you start flexing your peptide muscles, you need to learn the proper way to reconstitute them. Penetrate the peptide vial as gently as you can. Good practice for the compounding of lyophilized products would also include batching in a controlled environment and in sealed tanks, particularly if the solution is to be stored prior to sterilization. The container can be re-entered multiple times (usually by a sterile needle) and the benzyl alcohol is added to ensure that bacteria does not grow in the water as diluting medications with tainted water can have some severe consequences. One vial of BPC 157 contains 5mg, which also means 5000mcg. Another method of sterilization that has been practiced is the use of gaseous ethylene oxide. This method can preserve the peptides stability and activity for several months to years, depending on the peptides properties and storage conditions. Research peptides present great potential in emerging clinical contexts, such as combating symptoms of cardiovascular and metabolic diseases, as well as improving reproductive health [11]. These include subcutaneous, intramuscular, intravenous, and intradermal injection routes [. Haven't had any problems with this bacteriostatic water. It is simply water that has gone through purification and distillation processes for its safe use in various therapeutic contexts, namely injections, dilution, and irrigation. Why is Water Essential to Reconstitution? HCG solutions are to be refrigerated to prevent degradation [19]. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. See PRECAUTIONS. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Plus, peptide solutions made with bacteriostatic water resist contamination. Many people have this mentality that bacteriostatic water and sterile water are the same thing, and that can bring disastrous results. Beisswenger, H.L. 51.222.156.250 Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). As discussed earlier, peptide mixing water is used to dissolve/dilute the lyophilized peptides. Methylprednisolone sodium succinate has the same . Sterile water is available for injection use such as intravenous, intramuscular and subcutaneous. These Terms constitute the entire agreement between Buckle LLC and you in relation to your use of this Website, and supersede all prior agreements and understandings. Also, nothing contained on this Website shall be interpreted as advising you. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. Lets explore their points of similarity and difference to understand their appropriate uses. Bacteriostatic water is water with benzyl alcohol. Water for Injection, USP is chemically designated H2O. Cloudflare Ray ID: 7c0dd62a4baa8226 1. : the action of reconstituting or state of being reconstituted. Please enter the email address for your account. These lyophilizers can only have their inside surfaces wiped with a chemical agent that may be a sterilant. ; New York City, Nov. 13, 1968. Daptomycin RF has a longer in-use shelf period although times vary based on dosage form (vial, IV bag, or syringe) and diluent used. Bacteriostatic Water Vs. Sterile Water Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. As with any ethylene oxide treatment, humidification is necessary. Validation of this handling should also include the use of filled vials of media. Bacteriostatic water is commonly used for the injection of therapeutic compounds. Slowly extract the bacteriostatic water until the solution reaches your desired level. Okay, we made up that statistic, but its probably close to the truth. corrective measures. In no event shall Buckle LLC, nor any of its officers, directors and employees, shall be held liable for anything arising out of or in any way connected with your use of this website whether such liability is under contract. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.. Wir bieten unseren Kunden mit ntzlichen Informationen und Ratschlge, die sie bentigen, fundierte Entscheidungen zu treffen, ihre Ziele zu erreichen. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. To answer this question, let's look at an example of Dr. Smith, a pharmaceutical scientist who needs to prepare a peptide solution for a clinical trial. Touched on earlier, another key difference is multiple uses. Definitely be educated on the similarities and differences and have confidence when purchasing. We strive to never have a piece of inaccurate information on this website. The container requires no vapor barrier to maintain the proper labeled volume. The video I would recommend is embedded below. Bacteriostatic Water vs reconstitution solution whats the difference? So, if you want to maximize the efficacy of your peptides, follow our guide step-by-step, and soon youll be a reconstitution pro. We do the complete research and follow standards before starting the manufacturing process. This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. May contain hydrochloric acid for pH adjustment. If an adverse reaction does occur, discontinue the infusion, evaluate . In these Website Standard Terms and Conditions, Your Content shall mean any audio, video text, images or other material you choose to display on this Website. In closing, bacteriostatic water is often the preferred choice for injections in a range of contexts. This solution has no antimicrobial agents. Both substances are sterile solvents formulated for use in medical settings. You may be surprised to learn that they are not interchangeable [5]. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. Immediately you can gauge which is appropriate based on allergies. Correctly reconstituting peptides is essential in their effectiveness. If any provision of these Terms is found to be invalid under any applicable law, such provisions shall be deleted without affecting the remaining provisions herein. However, you are not allowed to assign, transfer, or subcontract any of your rights and/or obligations under these Terms. However, they do differ in their composition as the bacteriostatic water contains 0.9% benzyl alcohol as a preservative. Two sterile solutions that are commonly used are bacteriostatic water and sterile water. Peptide reconstitution is a complicated and confusing process for many. Injection of HGH is considered safe when prescribed by a doctor.
is reconstitution solution the same as bacteriostatic water?
